![]() ![]() ![]() Healthcare professionals are advised to monitor treatment using clinical parameters indicative of appropriate response (i.e. ![]() In these assays, the FXa inhibitor dissociates from andexanet alfa, resulting in the detection of falsely elevated anti-FXa activity levels, and consequently a substantial underestimation of the reversal activity of andexanet alfa. Treatment monitoring after administration of andexanet alfa should not be based on anti-FXa activity assays. MRHA/CHM advice: Ondexxya® (andexanet alfa): Commercial anti-FXa activity assays are unsuitable for measuring anti-FXa activity following administration of andexanet alfa (July 2020) Restriction: In line with NICE Guidance only Specific reversal agents are available for dabigatran (Praxbind▼, idarucizumab), and apixaban and rivaroxaban (Ondexxya▼, andexanet alfa). South Staffordshire Joint Formulary NHS Staffordshire and Stoke-on-Trent Integrated Care Boardįormulary Chapter 2: Cardiovascular system - Full Chapterĭirect-acting oral anticoagulants (DOACs): reminder of bleeding risk, including availability of reversal agentsĬlinicians to remain vigilant for signs and symptoms of bleeding complications during treatment with DOACs (apixaban, dabigatran, edoxaban, rivaroxaban), especially in patients with increased bleeding risks. South Staffordshire Joint Formulary Formulary ![]()
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