![]() ![]() ![]() Healthcare professionals are advised to monitor treatment using clinical parameters indicative of appropriate response (i.e. ![]() In these assays, the FXa inhibitor dissociates from andexanet alfa, resulting in the detection of falsely elevated anti-FXa activity levels, and consequently a substantial underestimation of the reversal activity of andexanet alfa. Treatment monitoring after administration of andexanet alfa should not be based on anti-FXa activity assays. MRHA/CHM advice: Ondexxya® (andexanet alfa): Commercial anti-FXa activity assays are unsuitable for measuring anti-FXa activity following administration of andexanet alfa (July 2020) Restriction: In line with NICE Guidance only Specific reversal agents are available for dabigatran (Praxbind▼, idarucizumab), and apixaban and rivaroxaban (Ondexxya▼, andexanet alfa). South Staffordshire Joint Formulary NHS Staffordshire and Stoke-on-Trent Integrated Care Boardįormulary Chapter 2: Cardiovascular system - Full Chapterĭirect-acting oral anticoagulants (DOACs): reminder of bleeding risk, including availability of reversal agentsĬlinicians to remain vigilant for signs and symptoms of bleeding complications during treatment with DOACs (apixaban, dabigatran, edoxaban, rivaroxaban), especially in patients with increased bleeding risks. South Staffordshire Joint Formulary Formulary ![]()
0 Comments
![]() ![]()
![]() ![]() It will trade on the NYSE (OWLT) and close in Q2. Baby monitoring system Owlet Baby Care becomes a unicorn of just over $1 bn through a SPAC (special purpose acquisition company) merger with Sandbridge Acquisition Corporation, backed by Sandbridge Capital and PIMCO private funds. It was one of the early healthcare unicorns, controversial in its business practices as far back as 2016, with customer churn, low margins, and high customer acquisition costs leading to unprofitability, plus a former CEO suing about his ouster after eight years. ![]() Zocdoc now claims to be profitable and has grown its network by 50 percent in some states. Zocdoc has changed its model in the past two years from a subscription basis–priced per provider–to a per-booking charge. Patient appointment setter Zocdoc also gathered $150 million in fresh funding–what’s termed growth financing from Francisco Partners, bringing their total financing to $376 million in 10 rounds. The pandemic and ‘lockdown loneliness’, as we’ve noted, kicked digital health and mental health funding into overdrive. According to Crunchbase News, among mental health startups, 141 were venture-backed within five years to the tune of $1.3 bn in investment. Talkspace, a direct-to-consumer digital therapy provider, went public earlier in January via a $1.4 bn SPAC. Lyra claims 2 million members in large companies like Pillsbury, Uber, and Morgan Stanley. In January, corporate mental health provider, Lyra Health, gained a Series E of $187 million, bringing its valuation to $2 bn. On 1 February, Modern Health acquired Kip, another mental health platform that was also woman-founded, for an undisclosed amount. Modern Health provides for about 220 mid-sized companies an app platform combining therapy, coaching, and self-guided courses in 35 languages. The company claims a valuation of $1.17 bn plus status as the fastest entirely women-founded company in the US to hit the magic unicorn mark. ![]() Total funding now exceeds $167 million over the past two years. The latest is San Francisco-based Modern Health which closed a $74 million Series D investment round, led by Founders Fund with participation from Lachy Groom. Virtual behavioral health continues its hot run with two companies’ funding launching them into Unicorn Stratosphere valuations. ![]() ![]() ![]() Britannica Beyond We’ve created a new place where questions are at the center of learning.100 Women Britannica celebrates the centennial of the Nineteenth Amendment, highlighting suffragists and history-making politicians.COVID-19 Portal While this global health crisis continues to evolve, it can be useful to look to past pandemics to better understand how to respond today.Student Portal Britannica is the ultimate student resource for key school subjects like history, government, literature, and more.Demystified Videos In Demystified, Britannica has all the answers to your burning questions.This Time in History In these videos, find out what happened this month (or any month!) in history.#WTFact Videos In #WTFact Britannica shares some of the most bizarre facts we can find.Britannica Classics Check out these retro videos from Encyclopedia Britannica’s archives.Britannica Explains In these videos, Britannica explains a variety of topics and answers frequently asked questions.Chandrasekhar’s main purpose is to reconstruct Newton’s mathematical physics in contemporary language. Subrahmanyan Chandrasekhar’s Newton’s “Principia” for the Common Reader (Oxford University Press, 1995) addresses the student and the scientist with little interest in the historical context of Newton’s Principia. The same historian can also turn to William Harper’s Isaac Newton’s Scientific Method: Turning Data into Evidence About Gravity and Cosmology (Oxford University Press, 2011) for useful insights into the amazing amount of empirical work grounding Principia’s theoretical achievements. Niccolò Guicciardini’s Reading the “Principia”: The Debate on Newton’s Mathematical Methods for Natural Philosophy from 1687 to 1736 (Cambridge University Press, 1999) addresses the professional historian of science. However, the common reader differs widely from one author to the next. Mathematician Colin Pask’s Magnificent “Principia”: Exploring Isaac Newton’s Masterpiece belongs to a respectable tradition: books that attempt to translate the abstruse Principia for the common reader. ![]() ![]() ![]() If you need to delay video by 3.84 seconds, use a command like this: ffmpeg.exe -i "movie.mp4" -itsoffset 3.84 -i "movie.mp4" -map 1:v -map 0:a -c copy "movie-video-delayed.mp4" However, in the version I have, those settings don't apply to saving the stream. Negative means "move track backwards", as in advance its start time. ![]() Positive means "move track forward", as in delay its start time. ![]() ![]() If the audio and video are out-of-sync when watching the video, VLC makes it easy to adjust - so you can easily discover the exact offset that you need. lv.m4v (for Latvian and just because VLC prefers the. Ideally you won't be doing any encoding or changing encapsulation in this step ( uncheck those), you'll just set the name. Now you select the video only file (otherwise the audio will not be replaced, but will be added to the end of the audio track listing) and the audio language track you want:ĭon't forget to check the "Stream" option. Now you're going to open two files at once. It may save to memory very quickly, but still take another few minutes to actually sync to disc.ĭon't be alarmed if your disc shows something ridiculous like "76MB". Important: The playback bar represents the stream progress. I called mine the same as prior but with video-only just before the extension. You want Video and Keep original video track selected.Ĭhoose the output file. mp4 video without converting the audio?Ĭhoose a compatible container format (probably mp4 if you want it to work on blu-ray players with usb slots, or mkv for hipster stuff) |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |